Xia Lab
 
Hongwei Yang, M.D., Ph.D.

Research Fellow
Center for Neurologic Diseases
Brigham and Women's Hospital
Harvard Medical School
Harvard Institute of Medicine, HIM 610
77 Avenue Louis Pasteur
Boston, MA 02115-5716
(617) 525-5746 (lab)
(617) 525-5305 (fax)
email: hyang@rics.bwh.harvard.edu

 

Current Research Interests:

  •       Using zebrafish to study tumorigenesis, neurogenesis and neurodegeneration.

    Selected Original Reports:

  • 1.     Yang HW, Piao HY, Taki T, Chen T, Hashizume K, Ohnishi H, Bessho F, Yanagisawa M, Matsuo Y and Hayashi Y. Pattern of FHIT gene expression in normal and leukemic cells. Intl. J. Cancer, 1999; 81:897-901.

    2.     Xu F, Taki T, Yang HW, Hanada R, Hongo T, Ohnishi H, Kobayashi M, Bessho M, Yanagisawa M, Hayashi, Y.  Tandem duplication of the FLT3 gene is found in acute lymphoblastic leukaemia as well as acute myeloid leukaemia but not in myelodysplastic syndrome or juvenile chronic myelogeous leukaemia in Children. Brit. J  Haematol., 1999; 105, 155-162.

    3.     Yang HW, Piao HY, Chen YZ, Takita J, Kobayashi M, Taniwaki M, Hashizume K, Hanada R, Yamamoto K, Taki M, Bessho F, Yanagisawa M, Hayashi Y. The p73 gene is less involved in the development but involved in the progression of neuroblastoma. Intl. J. Mol. Med. 2000, 5(4):379-84.

    4.     Takita J, Yang HW, Bessho F, Hanada R, Yamamoto K, Kidd V, Teitz T, Wei T,  Hayashi Y. Absent or reduced expression of the caspase 8 gene occurs frequently in neuroblastoma, but not commonly in Ewing sarcoma or rhabdomyosarcomaMed Pediatr Oncol. 2000;35(6):541-3.

    5.     Yang HW, Hayashi Y. EWS-WT1 Fusion gene in desmoplastic small round cell tumors. Japanese Journal of Pediatric Surgery. 2000;32:1086-1089.

    6.     Liu M, Taketani T, Li R, Takita J, Taki T, Yang HW, Kawaguchi H, Ida H, Matsuo Y, Hayashi, Y. Loss of p73 gene expression in lymphoid leukemia cell lines is associated with hypermethylation. Leukemia Res., 2001, 25: 441-447.

    7.     Chen YZ, Soeda E, Yang HW, Takita J, Chai L, Horii A, Inazawa J, Ohki M, Hayashi Y. Homozygous Deletion in Neuroblastoma Cells Defined by a High-density STS Map Spanning Human Chromosome 1p36. Gene Chromosome & Cancer, 2001;31; 326-332

    8.     Yang HW, Chen YZ, Piao HY, Takita J, Soeda E, Hayashi Y. DNA fragmentation factor 45 (DFF45) gene at 1p36.2 is homozygously deleted and encodes variant transcripts in neuroblastoma cell lines. Neoplasia, 2001;3; 165-169.

    9.     Takita J, Yang HW, Chen Y, Hanada R, Yamamoto K, Kidd V, Teitz T, Hayashi Y.  Allelic Imbalance on Chromosome 2q and Alterations of the Caspase 8 gene in Neuroblastoma. Oncogene, 2001; 20; 4424-4432.

    10.  Zhao C, Takita J, Tanaka Y, Setou M, Nakagawa T, Taketa S, Yang HW, Terada S, Nakata T, Takei Y, Saito M, Tsuji S, Hayashi Y, Hirokawa N. Charcot-Marie-Tooth disease type 2A caused by mutation in a microtubule motor KIF1BbCell, 2001;105:587-597.

    11.  Yang HW, Chen YZ, Takita J, Soeda E, Piao HY, Hayashi Y. Genomic structure and mutational analysis of the human KIF1B gene which is homozygously deleted in neuroblastoma at chromosome 1p36.2. Oncogene, 2001;20; 5075-5083

    12.  Liu TX, Zhou Y, Kanki JP, Deng M, Rhodes J, Yang HW, Sheng XM, Zon LI, Look AT. Evolutionary conservation of zebrafish linkage group 14 with frequently deleted regions of human chromosome 5 in myeloid malignancies. Proc Natl Acad Sci U S A. 2002 99(9):6136-41.

    13.  Chen YY, Takita J, Chen YZ, Yang HW, Hanada R, Yamamoto K, Hayashi Y. Genomic structure and mutational analysis of the human KIF1Balpha gene located at 1p36.2 in neuroblastoma. Int J Oncol. 2003; 23(3):737-44.

    14.  Obana K, Yang HW, Piao HY, Taki T, Hashizume K, Hanada R, Yamamoto K, Tanaka Y, Toyoda Y, Takita J, Tsuchida Y, Hayashi Y. Aberrations of p16INK4A, p14ARF and p15INK4B genes in pediatric solid tumors. Int J Oncol. 2003;23(4):1151-7.

    15.  Yang HW,  Kutok JL, Lee NH, Piao HY, Fletcher CDM, Kanki JP, Look AT. Targeted Expression of Human MYCN Selectively Causes Pancreatic Neuroendocrine Tumors in Transgenic Zebrafish. Cancer Res. 2004; 64: 7256-7262.

    Education

    1987  MD         China Medical University, China

    1990  M.M       China Medical University, China

    1999 Ph.D.       University of Tokyo, Japan

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