Original Reports:
Original Reports
Citations:
1/2004
Citations in the field of Biology and Biochemistry: top 1% of the ISI Essential Science Indicators
Original Reports:
1.
Xia W, Dowhan W. In vivo evidence for the
involvement of anionic phospholipids in initiation of DNA replication in Escherichia
coli. Proc Natl Acad Sci USA
1995; 92: 783-787.
2.
Xia W, Dowhan W. Phosphatidylinositol cannot substitute for
phosphatidylglycerol in supporting cell growth of Escherichia coli.
J Bacteriol. 1995; 177: 2926-2928.
3.
Tropp B, Ragolia L, Xia W, Dowhan W, Milkman R, Rudd K, Ivanisevic
R, Savic D. Identity of the Escherichia coli cls and nov
genes. J Bacteriol. 1995; 177: 5155-5157.
4.
Xia W*, Zhang J*, Kholondenko D, Citron M, Podlisny
MB, Teplow DB, Haass C, Seubert P, Koo EH, Selkoe DJ. Enhanced
production and oligomerization of the 42-residue amyloid b-protein by Chinese
hamster ovary cells stably expressing mutant presenilins. J Biol
Chem. 1997; 272: 7977-7982.
5.
Citron M, Westaway D, Xia W, Carlson G, Diehl T, Levesgue G,
Johnson-Wood K, Lee M, Seubert P, Davis A, Kholodenko D, Motter R,
Sherrington R, Perry B, Yao H, Strome R, Lieberburg I, Rommens J, Kim S,
Schenk D, Fraser P, St George-Hyslop P, Selkoe DJ. Mutant
presenilins of Alzheimer's disease increase production of 42-residue
amyloid b-protein
in both transfected cells and transgenic mice. Nature Med.
1997; 3: 67-72.
6.
Podlisny MB, Citron M, Amarante P, Sherrington R, Xia W, Zhang J,
Diehl T, Levesque G, Fraser P, Haass C, Koo EHM, Seubert P, St.
George-Hyslop P, Teplow DB, Selkoe DJ. Presenilin proteins undergo
heterogeneous endoproteolysis between Thr291 and Ala299 and
occur as stable N- amd C-terminal fragments in normal and Alzheimer brain
tissue. Neurobiology of Disease 1997; 3:
325-337.
7.
Shen J, Bronson RT, Chen DF, Xia W, Selkoe DJ, Tonegawa S.
Skeletal and CNS defects in presenilin-1 deficient mice. Cell
1997; 89: 629-640.
8.
Xia W, Zhang J, Perez R, Koo EH, Selkoe DJ. Interaction
between amyloid precursor protein and presenilins in mammalian
cells: Implications for the pathogenesis of Alzheimer
disease. Proc Natl Acad Sci USA
1997; 94: 8208-8213.
9.
Wolfe M, Citron M, Diehl T, Xia W, Donkor I, Selkoe DJ. A
Substrate-Based Difluoroketone Selectively Inhibits Alzheimer’s g-Secretase Activity. J Medicinal
Chem 1998; 41: 6-9.
10. Zhang J, Kang D, Xia W, Okochi M, Mori H, Selkoe DJ,
Koo EH. Subcellular Distribution and Turnover of Presenilins in
Transfected Cells. J Biol Chem. 1998; 273:
12436-12442.
11. Lee S, Liyanage U, Bickel P, Xia W, Lansbury P,
Kosik K. A Detergent-Insoluble Membrane Compartment Contains Aß in
vivo. Nature Med. 1998; 4:730-734.
12. Citron M, Eckman C, Diehl T, Corcoran C, Ostaszewski
B, Xia W, Levesque G, St. George-Hyslop P, Younkin S, Selkoe DJ.
Additive Effects of PS1 and APP Mutations on Secretion of the 42-residue
Amyloid ß-protein are Mediated by the PS1 Holoprotein. Neurobiology
of Disease 1998; 5:107-116.
13. Xia M, Berezovska O, Kim T, Xia W, Liao A, Tanzi R,
Selkoe DJ, Hyman BT. Lack of specific association of Presenilin 1
(PS-1) protein with plaques and tangles in Alzheimer’s disease. J
Neurological Sciences 1998; 158:15-23.
14. Querfurth HW, Jiang J, Xia W, Selkoe DJ.
Enhancer function and novel DNA binding protein activityin the near
upstream ßAPP gene promoter. Gene 1999; 232: 125-141.
15. Xia W, Zhang J, Ostaszewski BL, Kimberly WT, Seubert
P, Koo EH, Shen J, Selkoe DJ. Presenilin 1 regulates the processing
of APP C-terminal fragments and the generation of amyloid ß-protein in ER
and Golgi. Biochemistry 1998; 37:16465-16471.
16. Wolfe M, Xia W, Moore CL, Leatherwood DD,
Ostaszewski B, Rahmati T, Donkor IO, Selkoe DJ. Peptidomimetic probes and
molecular modeling suggest Alzheimer’s g-secretase is an intramembrane-cleaving
aspartyl protease. Biochemistry 1999, 38: 4720-4727.
17. Wolfe M*, Xia W*, Ostaszewski BL,
Diehl TS, Selkoe DJ. Two unusual transmembrane aspartates in
presenilin 1 are required for both presenilin endoproteolysis and g-secretase
activity. Nature 1999, 398: 513-517.
18. Perez RG, Soriano S, Hayes JD, Ostaszewski BL, Xia
W, Selkoe DJ, Chen X, Stokin GB, and Koo EH. Mutagenesis Identifies New
Signals for ß-Amyloid Precursor Protein Endocytosis, Turnover, and the
Generation of Secreted Fragments, Including Aß42. J Biol Chem
1999, 274: 18851-18856.
19. Wolfe M, De Los
Angeles J, Miller DD, Xia W, Selkoe DJ. Are
Presenilins Intramembrane-Cleaving Proteases? Implications for the Molecular
Mechanism of Alzheimer’s Disease. Biochemistry 1999, 38,
11223-11230.
20. Kimberly WT, Xia W, Rahmati T, Wolfe MS, Selkoe
DJ. The transmembrane aspartates in presenilin 1 and 2 are
obligatory for g-secretase
activity and amyloid ß-protein generation. J Biol Chem
2000, 275, 3173-3178.
21. Berezovska O, Jack C, McLean P, Aster JC, Hicks C,
Xia W, Wolfe M, Kimberly WT, Weinmaster G, Selkoe DJ, Hyman BT.
Aspartate Mutations in Presenilin and g-Secretase
Inhibitors Both Impair Notch1 Proteolysis and Nuclear Translocation with
Relative Preservation of Notch1 Signaling. J Neurochem.
2000, 75, 583-593.
22. Esler WP, Kimberly WT, Ostaszewski BL, Diehl TS, Moore CL, Tsai JY,
Rahmati T, Xia W, Selkoe DJ, Wolfe MS. Transition-state analogue
inhibitors of g-secretase bind
directly to presenilin-1. Nat Cell Biol. 2000, 2, 428-434.
23. Yoo AS, Cheng I, Chung S, Grenfell TZ, Lee H,
Pack-Chung E, Handler M, Shen J, Xia W, Tesco G, Saunders AJ, Ding K,
Frosch MP, Tanzi RE, Kim TW. Presenilin-mediated modulation of
capacitative calcium entry. Neuron
2000, 27, 561-72.
24. Berezovska O, Jack C, McLean P, Aster JC, Hicks C,
Xia W, Wolfe MS, Weinmaster G, Selkoe DJ, Hyman BT. Rapid Notch1
nuclear translocation after ligand binding depends on presenilin-associated
gamma-secretase activity. 2000, Ann N Y Acad Sci, 920, 223-6.
25. Xia W@, Ostaszewski BL, Kimberly WT,
Rahmati T, Moore CL, Wolfe MS, Selkoe DJ. FAD Mutations in Presenilin-1
or Amyloid Precursor Protein Decrease the Efficacy of a g-Secretase Inhibitor: a Direct
Involvement of PS1 in g-Secretase
Cleavage Complex. Neurobiol. Disease, 2000, 7, 673-681.
26. Xia W*@, Ray WJ*,
Ostaszewski BL, Rahmati T, Kimberly WT, Wolfe M, Zhang J, Goate AM,
Selkoe DJ. Presenilin Complexes with the C-terminal Fragments of
Amyloid Precursor Protein at the Sites of Amyloid ß-Protein
Generation. Proc Natl Acad Sci USA.,
2000, 97, 9299-9304.
27. Tekirian TL, Merriam DE, Marshansky V, Miller J,
Crowley AC, Chan H, Ausiello D, Brown D, Buxbaum JD, Xia W, Wasco W.
Subcellular localization of presenilin 2 endoproteolytic
C-terminal fragments. Brain Res Mol Brain Res. 2001, 96,
14-20.
28. Sun X, Cole GM, Chub T, Xia W, Galasko D, Yamaguchi
H, Tanemura K, Frautschy SA, Takashima A. Intracellular Aß is
increased by okadaic acid exposure in transfected neuronal and
non-neuronal cell lines. Neurobiol. Aging, 2002, 23,
195-203.
29. Esler WP, Das C, Campbell WA, Kimberly WT, Kornilova
AY, Diehl TS, Ye W, Ostaszewski BL, Xia W, Selkoe DJ, Wolfe MS.
Amyloid-lowering isocoumarins are not direct inhibitors of g-secretase. Nat
Cell Biol. 2002, 4, E110-111.
30. Campbell
WA, Iskandar M, Reed MLO,
Xia W@. Endoproteolysis of presenilin in vitro:
inhibition by a γ-secretase inhibitor. Biochemistry
2002, 41, 3372-3379.
31. Yang LB, Lindholm K, Yan R, Citron M, Xia, W, Yang,
X L, Sue L, Wong, P, Price, D, Li, R, Shen, Y. Elevated β-secretase expression
and enzymatic activity detected in sporadic Alzheimer disease. Nat
Med 2003, 9, 3-4.
32. Réchards M, Xia W, Oorschot V, Selkoe DJ, Klumperman
J. Presenilin-1 exists in both pre- and post-Golgi
compartments. Traffic, 2003, 4, 553-565.
33. Lee MS, Kao SC, Lemere CA, Xia W, Tseng HC, Zhou Y,
Neve R, Ahlijanian MK, Tsai LH. APP processing is regulated by
cytoplasmic phosphorylation. J Cell Biol. 2003, 163, 83-95.
34. Campbell
WA, Reed MLO, Wolfe, M, Xia
W@. Presenilin Endoproteolysis Mediated by an
Aspartyl Protease Activity Pharmacologically Distinct from
γ-Secretase. J Neurochem 2003, 85, 1563-1574.
35. Baulac S, Lavoie M, Kimberly W, Strahle J, Wolfe M,
Selkoe D and Xia W@. Functional γ-secretase complex assembly in
Golgi/trans-Golgi network: interactions among presenilin, nicastrin,
Aph1, Pen-2 and γ-secretase
substrates. Neurobiol Dis. 2003, 14, 194-204.
36. Harnasch M, Grau S, Behrends C, Dove S, Hochschild
A, Iskandar M, Xia W, Ehrmann M Characterization of
presenilin-amyloid precursor interaction using bacterial expression and
two-hybrid systems for human membrane proteins. Mol. Mem. Biol.
2004, 21, 1-11.
37. Baulac S, Lavoie M, Strahle J, Schlossmacher M, and
Xia W@. Dimerization of Parkinson disease-causing DJ-1
and formation of high molecular weight complexes in human brain. Mol. Cell. Neurosci. 2004,
27, 236-246.
38. Rechards M, Xia W, Oorschot V, van Dijk S, Annaert
W, Selkoe DJ, Klumperman J. Presenilin-1-mediated retention of
APP-derivatives in early biosynthetic compartments. Traffic,
2006, 7, 354-364.
39. Liu T, Lu, J, Wang Y, Campbell WA, Huang L, Zhu J,
Xia W@, Wong STC. Computerized image analysis for
quantitative neuronal phenotyping in zebrafish. J Neurosci
Methods. 2006, 153, 190-202.
40. Campbell WA, Yang H, Zetterberg H, Baulac S, Sears
JA, Liu T, Wong STC, Zhong TP, Xia W@. Zebrafish
lacking Alzheimer presenilin enhancer 2 (Pen-2) demonstrate excessive p53
dependent apoptosis and neuronal loss. J Neurochem. 2006,
96, 1423-40.
41. Pastorino, L, Sun, A, Lu, P ., Zhou, X Z, Balastik,
M, Finn, G, Wulf, G, Lim, J, Li, S H, Li, X, Xia, W, Nicholson, L and Lu,
K P. Pin1-catalyzed prolyl isomerization regulates amyloid
precursor protein processing and Aβ production. Nature 2006, 440, 528-534.
42. Salehi A, Delcroix JD, Belichenko PV, Zhan K, Wu C, Valletta JS, Takimoto-Kimura R, Kleschevnikov AM, Sambamurti K, Chung PP, Xia W, Villar A, Campbell WA, Kulnane LS, Nixon RA, Lamb BT, Epstein CJ, Stokin GB, Goldstein LS, Mobley WC. Increased App Expression in a Mouse
Model of Down's Syndrome Disrupts NGF Transport and Causes Cholinergic
Neuron Degeneration. Neuron
51, 29-42.
43. Zetterberg H, Campbell
WA, Yang HW, Xia W.
The cytosolic loop of the gamma -secretase component presenilin enhancer
2 (Pen-2) protects zebrafish embryos from apoptosis. J Biol
Chem. 2006, 281, 11933-9.
(* equal contribution; @ corresponding
author)
